Featured
New Immune Pathway in Dengue: A Breakthrough for
Researchers have identified a new IL-21+ T-cell subset that drives excessive antibody responses, worsening severe dengue cases. This breakthrough offers new insights for early diagnosis, improved vaccine development, and targeted treatments, marking a significant step forward in combating dengue globally.
SProtFP: a machine learning-based method for
SProtFP is the first ML-based tool that assigns prokaryotic small proteins to systematically defined functional categories.
A delicate interplay between the immune system
A new study has uncovered a critical mechanism that drives the inflammatory bowel disease (IBD), shedding light on the intricate connection between the immune system and nutrient metabolism.
Identification of pan-serotype drug candidates
Using virtual screening methodologies, two small molecule compounds were identified with favorable drug-like properties and can be developed as a treatment for Dengue virus
A novel structure-based method to predict the
Using machine learning, researchers at NII develop a novel structure-based method (SG-ML-PLAP) to predict the strength of protein-drug (ligand) binding. This new method significantly enhances the accuracy of binding energy calculation which is a key step in structure-based drug discovery.
Status, stress and responses
Researchers at the BRIC-NII have unraveled a critical role of PARP1 enzyme in DNA damage response and metabolic homeostasis.
Rethinking immune strategies: T cell metabolism
Research on T-cell metabolism with far-reaching implications for treating infections, autoimmune disorders, and even allergies.
A tale of two proteins : Orchestrating oogenesis
In today’s world, the rising concerns over accelerated reproductive aging in women highlights the need to better understand the factors that impact fertility.
From lungs to liver: Liver cells as a novel niche
New research from BRIC-NII provides evidence that the Mycobacterium tuberculosis bacteria infects liver cells (hepatocytes) leading to metabolic dysfunction
A new avenue in the management of fatal brain
A new avenue in the management of fatal brain diseases
Helical domain changes between human GBP3 and its
Only the full version of hGBP3 can stop the hepatitis C virus (HCV) from multiplying. This suggests that the protein’s shape—specifically, forming a hexamer—is key to its antiviral power.
Mitochondrial acyl carrier protein in Leishmania
The study reveals unique structural and functional features of LmACP, distinct from prokaryotic and plastid ACPs
New drug candidates to overcome chemoresistance
Researchers identified three FDA-approved drugs that disrupt a key protein interaction, overcoming chemoresistance in colon cancer.
miR-449a regulates neuronal cell cycle and
A study that highlights the therapeutic potential of miR-449a in providing relief to AD patients by improving cognitive defects
Latest News
From lungs to liver: Liver cells as a novel niche
New research from BRIC-NII provides evidence that the Mycobacterium tuberculosis bacteria infects liver cells (hepatocytes) leading to
A new avenue in the management of fatal brain
A new avenue in the management of fatal brain diseases
Helical domain changes between human GBP3 and its
Only the full version of hGBP3 can stop the hepatitis C virus (HCV) from multiplying. This suggests that the protein’s shape—specifically, forming
Mitochondrial acyl carrier protein in Leishmania
The study reveals unique structural and functional features of LmACP, distinct from prokaryotic and plastid ACPs
New drug candidates to overcome chemoresistance
Researchers identified three FDA-approved drugs that disrupt a key protein interaction, overcoming chemoresistance in colon cancer.
miR-449a regulates neuronal cell cycle and
A study that highlights the therapeutic potential of miR-449a in providing relief to AD patients by improving cognitive defects
Biochemistry
Biochemistry
Helical domain changes between human GBP3 and its splice
Only the full version of hGBP3 can stop the hepatitis C virus (HCV) from multiplying. This suggests that the protein’s shape—specifically, forming a hexamer—is key to its antiviral power.
Bioinformatics / Structural Biology
Bioinformatics / Structural Biology
SProtFP: a machine learning-based method for functional
SProtFP is the first ML-based tool that assigns prokaryotic small proteins to systematically defined functional categories.
Cancer Biology
Cancer Biology
Status, stress and responses
Researchers at the BRIC-NII have unraveled a critical role of PARP1 enzyme in DNA damage response and metabolic homeostasis.
Cell Signaling
Cell Signaling
From lungs to liver: Liver cells as a novel niche in TB
New research from BRIC-NII provides evidence that the Mycobacterium tuberculosis bacteria infects liver cells (hepatocytes) leading to metabolic dysfunction
Infections / Immunity
Infections / Immunity
New Immune Pathway in Dengue: A Breakthrough for Next-Gen
Researchers have identified a new IL-21+ T-cell subset that drives excessive antibody responses, worsening severe dengue cases. This breakthrough offers new insights for early diagnosis, improved vaccine development, and targeted treatments, marking a significant step forward in combating dengue globally.
Genetics
Genetics
A tale of two proteins : Orchestrating oogenesis and
In today’s world, the rising concerns over accelerated reproductive aging in women highlights the need to better understand the factors that impact fertility.