The National Institute of Immunology conducted an open day on 11 January 2024 on the theme of “India’s Vaccine Self-Reliance”. The open day was used as a platform to showcase the India International Science Festival 2023 and encourage the students as wells as public at large to visit and participate in the festival. The open-day program consisted of public talks, poster sessions, lab demos, sophisticated research facility visits, discussions, quizzes and games. Dr Shekhar Mande, Former DG of CSIR and National President of VIBHA delivered an online talk on “History of Biomedical Sciences in India” and interacted with the attending students. Dr Nimesh Gupta, Faculty of NII, unpacked the science behind vaccines while illustrating the success story of India’s vaccine self-reliance. During the day, one of the main events was a poster session showcasing the projects and research of NII researchers. The topics covered a wide range, including immunology, infectious and chronic disease biology, molecular and cellular biology, chemical biology, structural biology, and computational biology. Other events included visits to NII research facilities, games, and quizzes. The open day featured a special science exhibition and a demonstration by the National Science Museum, New Delhi. The open day saw the participation of over 150 students and teachers from schools and colleges of Delhi NCR.